Catastrophism

@book{price1926evolutionary11,
    author = "Price, G. M",
    title = "Evolutionary Geology and the New Catastrophism",
    year = "1926",
    publisher = "Mountain View, California, Pacific Press",
    note = "talkorigins\_source = {true}; raw\_reference = {Price, G. M., 1926, Evolutionary Geology and the New Catastrophism: Mountain View, California, Pacific Press.}"
}

@misc{velikovsky1950worlds15,
    author = "Velikovsky, I",
    title = "Worlds in Collision",
    year = "1950",
    howpublished = "Garaden City, New York, Doubleday and Co., 401 p",
    note = "talkorigins\_source = {true}; raw\_reference = {Velikovsky, I., 1950, Worlds in Collision: Garaden City, New York, Doubleday and Co., 401 p.}"
}

@misc{newell1963crises9,
    author = "Newell, N. D",
    title = "Crises in the history of life",
    year = "1963",
    howpublished = "Scientific American, v. 208, no. 2, p. 77-92",
    note = "talkorigins\_source = {true}; raw\_reference = {Newell, N. D., 1963, Crises in the history of life: Scientific American, v. 208, no. 2, p. 77-92.}"
}

@misc{velikovsky1965untitled17,
    author = "Velikovsky, I",
    title = "(?), Earth In Upheaval",
    year = "1965",
    howpublished = "New York, Dell",
    note = "talkorigins\_source = {true}; raw\_reference = {Velikovsky, I., 1965(?), Earth In Upheaval: New York, Dell.}"
}

@misc{velikovsky1965worlds16,
    author = "Velikovsky, I",
    title = "Worlds in Collision",
    year = "1965",
    howpublished = "New York, Dell; First printing, Doubleday, New York, 1950",
    note = "talkorigins\_source = {true}; raw\_reference = {Velikovsky, I., 1965, Worlds in Collision: New York, Dell; First printing, Doubleday, New York, 1950.}"
}

@misc{gould1975catastrophes7,
    author = "Gould, S. J",
    title = "Catastrophes and steady-state earth",
    year = "1975",
    howpublished = "Natural History Magazine, v. 84, no. 2, p. 14-18",
    note = "talkorigins\_source = {true}; raw\_reference = {Gould, S. J., 1975, Catastrophes and steady-state earth: Natural History Magazine, v. 84, no. 2, p. 14-18.}"
}

@misc{gould1975velikovsky6,
    author = "Gould, S. J",
    title = "Velikovsky in Collision",
    year = "1975",
    howpublished = "Natural History Magazine, no. March, p. 20-26",
    note = "talkorigins\_source = {true}; raw\_reference = {Gould, S. J., 1975, Velikovsky in Collision: Natural History Magazine, no. March, p. 20-26.}"
}

@misc{editors1976velikovsky10,
    author = "Editors, Pense",
    title = "Velikovsky Reconsidered",
    year = "1976",
    howpublished = "Garden City, New York, Doubleday and Co., 260 p",
    note = "talkorigins\_source = {true}; raw\_reference = {Pense Editors, 1976, Velikovsky Reconsidered: Garden City, New York, Doubleday and Co., 260 p.}"
}

@book{ransom1976the12,
    author = "Ransom, C. J",
    title = "The Age of Velikovsky",
    year = "1976",
    publisher = "Glassboro, NJ, Kronos Press, 274 p",
    note = "talkorigins\_source = {true}; raw\_reference = {Ransom, C. J., 1976, The Age of Velikovsky: Glassboro, NJ, Kronos Press, 274 p.}"
}

@book{asimov1977foreward1,
    author = "Asimov, I",
    title = "Foreward, in Goldsmith, D., ed., Scientists Confront Velikovsky",
    year = "1977",
    publisher = "Ithaca, New York, Cornell University Press, p. 7-15",
    note = "talkorigins\_source = {true}; raw\_reference = {Asimov, I., 1977, Foreward, in Goldsmith, D., ed., Scientists Confront Velikovsky: Ithaca, New York, Cornell University Press, p. 7-15.}"
}

@book{goldsmith1977scientists5,
    author = "Goldsmith, D",
    title = "Scientists Confront Velikovsky",
    year = "1977",
    publisher = "Ithaca, New York, Cornell University Press, 183 p",
    note = "talkorigins\_source = {true}; raw\_reference = {Goldsmith, D., 1977, Scientists Confront Velikovsky: Ithaca, New York, Cornell University Press, 183 p.}"
}

@book{morrison1977planetary8,
    author = "Morrison, D",
    title = "Planetary Astronomy and Velikovsky's Catastrophism, in Goldsmith, D., ed., Scientists Confront Velikovsky",
    year = "1977",
    publisher = "Ithaca, New York, Cornell University Press, p. 145-176",
    note = "talkorigins\_source = {true}; raw\_reference = {Morrison, D., 1977, Planetary Astronomy and Velikovsky's Catastrophism, in Goldsmith, D., ed., Scientists Confront Velikovsky: Ithaca, New York, Cornell University Press, p. 145-176.}"
}

@book{sagan1977an13,
    author = "Sagan, C",
    title = {An Analysis of "Worlds in Collision", in Goldsmith, D., ed., Scientists Confront Velikovsky},
    year = "1977",
    publisher = "Ithaca, New York, Cornell University Press, p. 41-104",
    note = {talkorigins\_source = {true}; raw\_reference = {Sagan, C., 1977, An Analysis of "Worlds in Collision", in Goldsmith, D., ed., Scientists Confront Velikovsky: Ithaca, New York, Cornell University Press, p. 41-104.}}
}

@book{storer1977the14,
    author = "Storer, N. W",
    title = "The Sociological Context of the Velikovsky Controversy, in Goldsmith, D., ed., Scientists Confront Velikovsky",
    year = "1977",
    publisher = "Ithaca, New York, Cornell University Press, p. 29-39",
    note = "talkorigins\_source = {true}; raw\_reference = {Storer, N. W., 1977, The Sociological Context of the Velikovsky Controversy, in Goldsmith, D., ed., Scientists Confront Velikovsky: Ithaca, New York, Cornell University Press, p. 29-39.}"
}

@article{aveni1978a,
    author = "Aveni, Anthony F.",
    title = "A Marshaling of Arguments: Scientists Confront Velikovsky. Papers from an AAAS symposium, San Francisco, Feb. 1974. Donald Goldsmith, Ed. Cornell University Press, Ithaca, N.Y., 1977. 184 pp., illus. $8.95.",
    year = "1978",
    journal = "Science",
    url = "https://doi.org/10.1126/science.199.4326.288",
    doi = "10.1126/science.199.4326.288",
    number = "4326",
    openalex = "W2064524181",
    pages = "288-289",
    volume = "199"
}

@article{verschuur1978cosmic,
    author = "Verschuur, G. and Goldsmith, D. and Abell, George O.",
    title = "Cosmic Catastrophes and Scientists Confront Velikovsky",
    year = "1978",
    journal = "Physics Today",
    url = "https://doi.org/10.1063/1.2995147",
    doi = "10.1063/1.2995147",
    number = "8",
    pages = "56-59",
    volume = "31"
}

@misc{dury1980neocatastrophism4,
    author = "Dury, G. H",
    title = "Neocatastrophism? A further look",
    year = "1980",
    howpublished = "Progress in Physical Geography, v. 4, no. 3, p. 391-413",
    note = "talkorigins\_source = {true}; raw\_reference = {Dury, G. H., 1980, Neocatastrophism? A further look: Progress in Physical Geography, v. 4, no. 3, p. 391-413.}"
}

@misc{austin1984catastrophes2,
    author = "Austin, S. A",
    title = "Catastrophes in Earth History",
    year = "1984",
    howpublished = "A Source Book of Geological Evidence, Speculation and Theory: El Cajon, California, Institute for Creation Research, 318 p.; ICR Technical Monograph 13",
    note = "talkorigins\_source = {true}; raw\_reference = {Austin, S. A., 1984, Catastrophes in Earth History: A Source Book of Geological Evidence, Speculation and Theory: El Cajon, California, Institute for Creation Research, 318 p.; ICR Technical Monograph 13.}"
}

@book{berggren1984catastrophes3,
    author = "Berggren, W. A. and Van Couvering, J. A",
    title = "Catastrophes and Earth History",
    year = "1984",
    publisher = "The New Uniformitarianism: Princeton, New Jersey, Princeton University Press, 465 p",
    note = "talkorigins\_source = {true}; raw\_reference = {Berggren, W. A., and Van Couvering, J. A., 1984, Catastrophes and Earth History: The New Uniformitarianism: Princeton, New Jersey, Princeton University Press, 465 p.}"
}

@article{zenger1986lyell18,
    author = "Zenger, D. H",
    title = "Lyell and episodicity",
    year = "1986",
    journal = "Journal of Geological Education, v. 34, p. 10-13",
    note = "talkorigins\_source = {true}; raw\_reference = {Zenger, D. H., 1986, Lyell and episodicity: Journal of Geological Education, v. 34, p. 10-13.}"
}

@article{culliton1988scientists,
    author = "Culliton, Barbara J.",
    title = "Scientists Confront Misconduct",
    year = "1988",
    journal = "Science",
    url = "https://doi.org/10.1126/science.3175613",
    doi = "10.1126/science.3175613",
    number = "4874",
    pages = "1748-1749",
    volume = "241"
}

@incollection{chapman1989catastrophism,
    author = "Chapman, Clark R. and Morrison, David",
    title = "Catastrophism Gone Wild: The Case of Immanuel Velikovsky",
    year = "1989",
    booktitle = "Cosmic Catastrophes",
    url = "https://doi.org/10.1007/978-1-4899-6553-0\_13",
    doi = "10.1007/978-1-4899-6553-0\_13",
    openalex = "W44934322",
    pages = "183-196"
}

@article{crossref1991catastrophism,
    title = "Catastrophism: systems of earth history",
    year = "1991",
    journal = "Choice Reviews Online",
    url = "https://doi.org/10.5860/choice.28-4543",
    doi = "10.5860/choice.28-4543",
    number = "08",
    openalex = "W333513029",
    pages = "28-4543-28-4543",
    volume = "28"
}

@article{crossref2004perilous,
    title = "Perilous planet earth: catastrophes and catastrophism through the ages",
    year = "2004",
    journal = "Choice Reviews Online",
    url = "https://doi.org/10.5860/choice.41-4058",
    doi = "10.5860/choice.41-4058",
    number = "07",
    openalex = "W4240659375",
    pages = "41-4058-41-4058",
    volume = "41"
}

@article{koeberl2004perilous,
    author = "Koeberl, Christian",
    title = "Perilous planet Earth—Catastrophes and catastrophism through the ages: by Trevor Palmer",
    year = "2004",
    journal = "Meteoritics \& Planetary Science",
    url = "https://doi.org/10.1111/j.1945-5100.2004.tb00345.x",
    doi = "10.1111/j.1945-5100.2004.tb00345.x",
    number = "2",
    openalex = "W2015930546",
    pages = "347-348",
    volume = "39"
}

@article{grattan2005book,
    author = "Grattan, John P",
    title = "Book Review: Perilous planet Earth: catastrophes and catastrophism through the ages",
    year = "2005",
    journal = "The Holocene",
    url = "https://doi.org/10.1177/095968360501500519",
    doi = "10.1177/095968360501500519",
    number = "5",
    openalex = "W2045757096",
    pages = "778-778",
    volume = "15"
}

@article{hampton2005scientists,
    author = "Hampton, T.",
    title = "Scientists Confront Cloning Challenges",
    year = "2005",
    journal = "JAMA: The Journal of the American Medical Association",
    url = "https://doi.org/10.1001/jama.294.7.783",
    doi = "10.1001/jama.294.7.783",
    number = "7",
    openalex = "W2021509334",
    pages = "783-784",
    volume = "294"
}

@article{crossref2012the,
    title = "The Velikovsky heresies: Worlds in collision and ancient catastrophes revisited",
    year = "2012",
    journal = "Choice Reviews Online",
    url = "https://doi.org/10.5860/choice.49-6260",
    doi = "10.5860/choice.49-6260",
    number = "11",
    pages = "49-6260-49-6260",
    volume = "49"
}

@article{doi101016jenfcle2025102150,
    author = "Oter-Quintana, Cristina and Alameda-Cuesta, Almudena",
    title = "Catastrophism, myalgic encephalomyelitis-chronic fatigue syndrome and fibromyalgia: How research questions 'construct' realities.",
    year = "2025",
    journal = "Enfermeria clinica",
    url = "https://pubmed.ncbi.nlm.nih.gov/40288641/",
    doi = "10.1016/j.enfcle.2025.102150",
    pmid = "40288641"
}

Pain associated to injuries is a complex experience that combine both objective and-subjective elements and which strongly affects rehabilitation outcomes of sport injuries. It may affect directly (e.g., reducing range and strength of the movements involved in the physical therapy), or indirectly (e.g., decreasing adherence, reducing psychological readiness). Cognitive factors such as rumination and catastrophic thinking may affect the perception of pain and play a role in athletes management of pain during this journey. This study is aimed at longitudinally examine the predictive role of ruminative and catastrophism thinking in the perception of pain among injured athletes. A total of 22 injured male soccer players were recruited (Mean age = 20.3 years old; SD =.991). The assessment instruments used were ad hoc questionnaire of personal and sports-related variables; a questionnaire of current injury and sports injury history; the Pain Catastrophism Scale (PCS); the Ruminative Response Scale (RRS); and the Visual Analogue Scale (VAS) of Pain. The results showed a significant relationship between catastrophism, ruminative responses, and the perception of pain in injured athletes. Athletes with higher levels of catastrophism and rumination consistently reported a greater perception of pain. These results highlight the importance of targeted and tailored personalized psychological interventions for pain management to improve the rehabilitation process outcomes. Addressing individual coping strategies could improve recovery outcomes and support a more effective return -to-sport process.

@article{doi101038s41598025292470,
    author = "Gómez-Espejo, Verónica and Olmedilla, Aurelio and García-Mas, Alejandro and Ortega-Toro, Enrique and Sánchez-Iglesias, Iván and Rubio, Victor J",
    title = "Rumination catastrophism and pain in injured athletes.",
    year = "2025",
    journal = "Scientific reports",
    abstract = "Pain associated to injuries is a complex experience that combine both objective and-subjective elements and which strongly affects rehabilitation outcomes of sport injuries. It may affect directly (e.g., reducing range and strength of the movements involved in the physical therapy), or indirectly (e.g., decreasing adherence, reducing psychological readiness). Cognitive factors such as rumination and catastrophic thinking may affect the perception of pain and play a role in athletes management of pain during this journey. This study is aimed at longitudinally examine the predictive role of ruminative and catastrophism thinking in the perception of pain among injured athletes. A total of 22 injured male soccer players were recruited (Mean age = 20.3 years old; SD =.991). The assessment instruments used were ad hoc questionnaire of personal and sports-related variables; a questionnaire of current injury and sports injury history; the Pain Catastrophism Scale (PCS); the Ruminative Response Scale (RRS); and the Visual Analogue Scale (VAS) of Pain. The results showed a significant relationship between catastrophism, ruminative responses, and the perception of pain in injured athletes. Athletes with higher levels of catastrophism and rumination consistently reported a greater perception of pain. These results highlight the importance of targeted and tailored personalized psychological interventions for pain management to improve the rehabilitation process outcomes. Addressing individual coping strategies could improve recovery outcomes and support a more effective return -to-sport process.",
    url = "https://pmc.ncbi.nlm.nih.gov/articles/PMC12764906/",
    doi = "10.1038/s41598-025-29247-0",
    pmcid = "PMC12764906",
    pmid = "41365976"
}

Ferenczi's concept, the confusion of tongues between the child's language of tenderness and the adult's language of passion, explains that the child feels physically and psychically helpless and alone in the presence of an aggressor who disavows the traumatic acts, creating confusion for the child whether the traumatic experience happened at all. Fully dependent on the adults, the child adopts by introjecting the guilt and hate of the aggressor, in order to maintain the relationship with the adults. The confusion of tongues situation is linked to Ferenczi's complex construct, the identification with the aggressor, in understanding external traumas. With the concept of "autistic-contiguous position," Ogden identifies an area of pre-symbolic experience of a sensory nature, mainly centered on the surface of the skin as the starting point of mental life. These two concepts may permit us to be in touch with attitudes and beliefs in the exploration of individual and group defense mechanisms against climate change and environmental disasters. Using psychoanalytical knowledge, we can try to help people who are reluctant to fully acknowledge the seriousness of climate change, and so to change damaging behaviors in our relationship with the nonhuman world. The author critiques the repeated terrifying and bombarding images on TV and the Internet which would intend to inform about crises and disasters in the world, instead, those images paralyze psychic functioning. He describes how climate terrorism promotes the emergence of persecutory and primitive anxieties, even the activation of psychotic defenses. They foster the difficulties of getting in touch with deep-seated anxieties and remove a sense of responsibility and awareness of one's own participation in the creation of the damage.

@article{doi101057s11231025094959,
    author = "Schinaia, Cosimo",
    title = "Catastrophism and catastrophic images: Ferenczi's identification with the aggressor and Ogden's autistic-contiguous position as defence mechanisms.",
    year = "2025",
    journal = "American journal of psychoanalysis",
    abstract = {Ferenczi's concept, the confusion of tongues between the child's language of tenderness and the adult's language of passion, explains that the child feels physically and psychically helpless and alone in the presence of an aggressor who disavows the traumatic acts, creating confusion for the child whether the traumatic experience happened at all. Fully dependent on the adults, the child adopts by introjecting the guilt and hate of the aggressor, in order to maintain the relationship with the adults. The confusion of tongues situation is linked to Ferenczi's complex construct, the identification with the aggressor, in understanding external traumas. With the concept of "autistic-contiguous position," Ogden identifies an area of pre-symbolic experience of a sensory nature, mainly centered on the surface of the skin as the starting point of mental life. These two concepts may permit us to be in touch with attitudes and beliefs in the exploration of individual and group defense mechanisms against climate change and environmental disasters. Using psychoanalytical knowledge, we can try to help people who are reluctant to fully acknowledge the seriousness of climate change, and so to change damaging behaviors in our relationship with the nonhuman world. The author critiques the repeated terrifying and bombarding images on TV and the Internet which would intend to inform about crises and disasters in the world, instead, those images paralyze psychic functioning. He describes how climate terrorism promotes the emergence of persecutory and primitive anxieties, even the activation of psychotic defenses. They foster the difficulties of getting in touch with deep-seated anxieties and remove a sense of responsibility and awareness of one's own participation in the creation of the damage.},
    url = "https://pmc.ncbi.nlm.nih.gov/articles/8853093/",
    doi = "10.1057/s11231-025-09495-9",
    pmcid = "8853093",
    pmid = "40169868"
}

AIMS: After a total knee arthroplasty (TKA), up to 40% of patients suffer from chronic pain. Few studies have focused specifically on psychosocial factors as predictors of chronic pain after TKA. Our study aims to identify psychosocial risk factors of chronic pain after TKA and to identify an optimal threshold for significant scores in the multivariate analysis, using a receiver operating characteristic (ROC) curve. METHODS: This was a single-centre prospective study conducted from September 2022 to September 2023, involving 204 patients. The mean age was 70 years (SD 8.59), the mean BMI was 30.49 kg/m2 (SD 5.29), and 70.60% of patients were female (144/204). A form was administered before surgery to collect: Hospital Anxiety and Depression Scale (HADS), anxiety scale State-Trait Anxiety Inventory (STAI)-Y, Amsterdam Preoperative Anxiety and Information Scale (APAIS), Pain Catastrophizing Scale (PCS), and visual analogue scale (VAS). Univariate and multivariate logistic regression was used to determine the risk factors associated with chronic pain. To determine a threshold in the psychological scores associated with chronic pain, ROC curves were performed. RESULTS: A total of 36 patients (17.60%) met the definition of chronic pain, defined as VAS ≥ 4/10 at six months postoperatively. In the multivariate analysis, to be an employee or worker (β = 1.10, 95% CI 0.20 to 2.10, p = 0.018), anxiety STAI-YB (β = 0.03, 95% CI 0.01 to 0.06, p = 0.013), and catastrophism PCS (β = 0.04, 95% CI 0.02 to 0.06, p < 0.001) were associated with chronic pain after TKA. Using ROC analysis, we identified a threshold value of 44.5 for anxiety STAI-YB (sensitivity 57.58%, specificity 74.51%) and of 21.5 for catastrophism PCS (sensitivity 56,25 %, specificity 71.90%) of developing chronic pain after TKA. CONCLUSION: This study shows that the psychosocial profile of patients can be linked to the occurrence of chronic pain, and underlines the importance of a multidimensional approach to patient assessment and management.

@article{doi1013022633146267bjo20240270r1,
    author = "Croppi, Clara and Delaigue, Fanny and Guinebertière, Violaine and Devriese, Flore and Bizot, Pascal and Descamps, Jules and Nizard, Rémy and Bouché, Pierre-Alban",
    title = "Catastrophism and anxiety are risk factors of chronic pain after total knee arthroplasty: a prospective cohort study.",
    year = "2025",
    journal = "Bone \& joint open",
    abstract = "AIMS: After a total knee arthroplasty (TKA), up to 40\% of patients suffer from chronic pain. Few studies have focused specifically on psychosocial factors as predictors of chronic pain after TKA. Our study aims to identify psychosocial risk factors of chronic pain after TKA and to identify an optimal threshold for significant scores in the multivariate analysis, using a receiver operating characteristic (ROC) curve. METHODS: This was a single-centre prospective study conducted from September 2022 to September 2023, involving 204 patients. The mean age was 70 years (SD 8.59), the mean BMI was 30.49 kg/m2 (SD 5.29), and 70.60\% of patients were female (144/204). A form was administered before surgery to collect: Hospital Anxiety and Depression Scale (HADS), anxiety scale State-Trait Anxiety Inventory (STAI)-Y, Amsterdam Preoperative Anxiety and Information Scale (APAIS), Pain Catastrophizing Scale (PCS), and visual analogue scale (VAS). Univariate and multivariate logistic regression was used to determine the risk factors associated with chronic pain. To determine a threshold in the psychological scores associated with chronic pain, ROC curves were performed. RESULTS: A total of 36 patients (17.60\%) met the definition of chronic pain, defined as VAS ≥ 4/10 at six months postoperatively. In the multivariate analysis, to be an employee or worker (β = 1.10, 95\% CI 0.20 to 2.10, p = 0.018), anxiety STAI-YB (β = 0.03, 95\% CI 0.01 to 0.06, p = 0.013), and catastrophism PCS (β = 0.04, 95\% CI 0.02 to 0.06, p < 0.001) were associated with chronic pain after TKA. Using ROC analysis, we identified a threshold value of 44.5 for anxiety STAI-YB (sensitivity 57.58\%, specificity 74.51\%) and of 21.5 for catastrophism PCS (sensitivity 56,25 \%, specificity 71.90\%) of developing chronic pain after TKA. CONCLUSION: This study shows that the psychosocial profile of patients can be linked to the occurrence of chronic pain, and underlines the importance of a multidimensional approach to patient assessment and management.",
    url = "https://pmc.ncbi.nlm.nih.gov/articles/PMC12226953/",
    doi = "10.1302/2633-1462.67.BJO-2024-0270.R1",
    pmcid = "PMC12226953",
    pmid = "40626844"
}

The development of treatment methods used in the treatment of non-small cell lung cancer (NSCLC) is important to prevent problem of increasing mortality. However, the treatment methods used in clinical settings at the clinic are insufficient to eliminate this problem. For this purpose, it was aimed to determine whether the combination of docetaxel (DTX) and FH535 can be used as an anticancer agent candidate in A549 cells and whether it is a candidate drug combination that can be used in clinical treatment after in vivo studies. FH535 is a WNT signaling pathway inhibitor and is known to be overactive in NSCLC. In this study, the effects of DTX and WNT signaling pathway inhibitor FH535 used in NSCLC treatment on A549 and BEAS-2B cell lines were evaluated at the cellular level. While increasing the anticancer activity in A549 cells, the doses showing minimum toxic effect in BEAS-2B cells were determined by Real Time Cell Analysis method. Mitotic activity, BrdU cell proliferation assay and caspase 3,7 activity assay were performed for detailed analysis of the combination dose at cellular level. The results show that the combined dose had an antimitotic effect on A549 cells, causing mitotic catastrophism, while in BEAS-2B cells neither agent was more toxic than either agent alone, reducing mitotic activity and BrdU activity, leading the cell to mitotic catastrophism, while caspase 3,7 activity was unchanged. This study demonstrated for the first time the effects of the combination of DTX and FH535 on A549 and BEAS-2B cell lines.

@article{doi1014715cmb20257129,
    author = "Avşar, Eda Nur and Çetin, İdil",
    title = "Combined use of WNT signal pathway inhibitor FH535 and docetaxel causes mitotic catastrophism and antiproliferative effect in non-small cell lung cancer.",
    year = "2025",
    journal = "Cellular and molecular biology (Noisy-le-Grand, France)",
    abstract = "The development of treatment methods used in the treatment of non-small cell lung cancer (NSCLC) is important to prevent problem of increasing mortality. However, the treatment methods used in clinical settings at the clinic are insufficient to eliminate this problem. For this purpose, it was aimed to determine whether the combination of docetaxel (DTX) and FH535 can be used as an anticancer agent candidate in A549 cells and whether it is a candidate drug combination that can be used in clinical treatment after in vivo studies. FH535 is a WNT signaling pathway inhibitor and is known to be overactive in NSCLC. In this study, the effects of DTX and WNT signaling pathway inhibitor FH535 used in NSCLC treatment on A549 and BEAS-2B cell lines were evaluated at the cellular level. While increasing the anticancer activity in A549 cells, the doses showing minimum toxic effect in BEAS-2B cells were determined by Real Time Cell Analysis method. Mitotic activity, BrdU cell proliferation assay and caspase 3,7 activity assay were performed for detailed analysis of the combination dose at cellular level. The results show that the combined dose had an antimitotic effect on A549 cells, causing mitotic catastrophism, while in BEAS-2B cells neither agent was more toxic than either agent alone, reducing mitotic activity and BrdU activity, leading the cell to mitotic catastrophism, while caspase 3,7 activity was unchanged. This study demonstrated for the first time the effects of the combination of DTX and FH535 on A549 and BEAS-2B cell lines.",
    url = "https://pubmed.ncbi.nlm.nih.gov/39976912/",
    doi = "10.14715/cmb/2025.71.2.9",
    pmid = "39976912"
}