Katastrophismus

@book{price1926evolutionary11,
    author = "Price, G. M",
    title = "Evolutionary Geology and the New Catastrophism",
    year = "1926",
    publisher = "Mountain View, California, Pacific Press",
    note = "talkorigins\_source = {true}; raw\_reference = {Price, G. M., 1926, Evolutionary Geology and the New Catastrophism: Mountain View, California, Pacific Press.}"
}

@misc{velikovsky1950worlds15,
    author = "Velikovsky, I",
    title = "Worlds in Collision",
    year = "1950",
    howpublished = "Garaden City, New York, Doubleday and Co., 401 p",
    note = "talkorigins\_source = {true}; raw\_reference = {Velikovsky, I., 1950, Worlds in Collision: Garaden City, New York, Doubleday and Co., 401 p.}"
}

@misc{newell1963crises9,
    author = "Newell, N. D",
    title = "Crises in the history of life",
    year = "1963",
    howpublished = "Scientific American, v. 208, no. 2, p. 77-92",
    note = "talkorigins\_source = {true}; raw\_reference = {Newell, N. D., 1963, Crises in the history of life: Scientific American, v. 208, no. 2, p. 77-92.}"
}

@misc{velikovsky1965untitled17,
    author = "Velikovsky, I",
    title = "(?), Earth In Upheaval",
    year = "1965",
    howpublished = "New York, Dell",
    note = "talkorigins\_source = {true}; raw\_reference = {Velikovsky, I., 1965(?), Earth In Upheaval: New York, Dell.}"
}

@misc{velikovsky1965worlds16,
    author = "Velikovsky, I",
    title = "Worlds in Collision",
    year = "1965",
    howpublished = "New York, Dell; First printing, Doubleday, New York, 1950",
    note = "talkorigins\_source = {true}; raw\_reference = {Velikovsky, I., 1965, Worlds in Collision: New York, Dell; First printing, Doubleday, New York, 1950.}"
}

@misc{gould1975catastrophes7,
    author = "Gould, S. J",
    title = "Catastrophes and steady-state earth",
    year = "1975",
    howpublished = "Natural History Magazine, v. 84, no. 2, p. 14-18",
    note = "talkorigins\_source = {true}; raw\_reference = {Gould, S. J., 1975, Catastrophes and steady-state earth: Natural History Magazine, v. 84, no. 2, p. 14-18.}"
}

@misc{gould1975velikovsky6,
    author = "Gould, S. J",
    title = "Velikovsky in Collision",
    year = "1975",
    howpublished = "Natural History Magazine, no. March, p. 20-26",
    note = "talkorigins\_source = {true}; raw\_reference = {Gould, S. J., 1975, Velikovsky in Collision: Natural History Magazine, no. March, p. 20-26.}"
}

@misc{editors1976velikovsky10,
    author = "Editors, Pense",
    title = "Velikovsky Reconsidered",
    year = "1976",
    howpublished = "Garden City, New York, Doubleday and Co., 260 p",
    note = "talkorigins\_source = {true}; raw\_reference = {Pense Editors, 1976, Velikovsky Reconsidered: Garden City, New York, Doubleday and Co., 260 p.}"
}

@book{ransom1976the12,
    author = "Ransom, C. J",
    title = "The Age of Velikovsky",
    year = "1976",
    publisher = "Glassboro, NJ, Kronos Press, 274 p",
    note = "talkorigins\_source = {true}; raw\_reference = {Ransom, C. J., 1976, The Age of Velikovsky: Glassboro, NJ, Kronos Press, 274 p.}"
}

@book{asimov1977foreward1,
    author = "Asimov, I",
    title = "Foreward, in Goldsmith, D., ed., Scientists Confront Velikovsky",
    year = "1977",
    publisher = "Ithaca, New York, Cornell University Press, p. 7-15",
    note = "talkorigins\_source = {true}; raw\_reference = {Asimov, I., 1977, Foreward, in Goldsmith, D., ed., Scientists Confront Velikovsky: Ithaca, New York, Cornell University Press, p. 7-15.}"
}

@book{goldsmith1977scientists5,
    author = "Goldsmith, D",
    title = "Scientists Confront Velikovsky",
    year = "1977",
    publisher = "Ithaca, New York, Cornell University Press, 183 p",
    note = "talkorigins\_source = {true}; raw\_reference = {Goldsmith, D., 1977, Scientists Confront Velikovsky: Ithaca, New York, Cornell University Press, 183 p.}"
}

@book{morrison1977planetary8,
    author = "Morrison, D",
    title = "Planetary Astronomy and Velikovsky's Catastrophism, in Goldsmith, D., ed., Scientists Confront Velikovsky",
    year = "1977",
    publisher = "Ithaca, New York, Cornell University Press, p. 145-176",
    note = "talkorigins\_source = {true}; raw\_reference = {Morrison, D., 1977, Planetary Astronomy and Velikovsky's Catastrophism, in Goldsmith, D., ed., Scientists Confront Velikovsky: Ithaca, New York, Cornell University Press, p. 145-176.}"
}

@book{sagan1977an13,
    author = "Sagan, C",
    title = {An Analysis of "Worlds in Collision", in Goldsmith, D., ed., Scientists Confront Velikovsky},
    year = "1977",
    publisher = "Ithaca, New York, Cornell University Press, p. 41-104",
    note = {talkorigins\_source = {true}; raw\_reference = {Sagan, C., 1977, An Analysis of "Worlds in Collision", in Goldsmith, D., ed., Scientists Confront Velikovsky: Ithaca, New York, Cornell University Press, p. 41-104.}}
}

@book{storer1977the14,
    author = "Storer, N. W",
    title = "The Sociological Context of the Velikovsky Controversy, in Goldsmith, D., ed., Scientists Confront Velikovsky",
    year = "1977",
    publisher = "Ithaca, New York, Cornell University Press, p. 29-39",
    note = "talkorigins\_source = {true}; raw\_reference = {Storer, N. W., 1977, The Sociological Context of the Velikovsky Controversy, in Goldsmith, D., ed., Scientists Confront Velikovsky: Ithaca, New York, Cornell University Press, p. 29-39.}"
}

@article{aveni1978a,
    author = "Aveni, Anthony F.",
    title = "A Marshaling of Arguments: Scientists Confront Velikovsky. Papers from an AAAS symposium, San Francisco, Feb. 1974. Donald Goldsmith, Ed. Cornell University Press, Ithaca, N.Y., 1977. 184 pp., illus. $8.95.",
    year = "1978",
    journal = "Science",
    url = "https://doi.org/10.1126/science.199.4326.288",
    doi = "10.1126/science.199.4326.288",
    number = "4326",
    openalex = "W2064524181",
    pages = "288-289",
    volume = "199"
}

@article{verschuur1978cosmic,
    author = "Verschuur, G. and Goldsmith, D. and Abell, George O.",
    title = "Cosmic Catastrophes and Scientists Confront Velikovsky",
    year = "1978",
    journal = "Physics Today",
    url = "https://doi.org/10.1063/1.2995147",
    doi = "10.1063/1.2995147",
    number = "8",
    pages = "56-59",
    volume = "31"
}

@misc{dury1980neocatastrophism4,
    author = "Dury, G. H",
    title = "Neocatastrophism? A further look",
    year = "1980",
    howpublished = "Progress in Physical Geography, v. 4, no. 3, p. 391-413",
    note = "talkorigins\_source = {true}; raw\_reference = {Dury, G. H., 1980, Neocatastrophism? A further look: Progress in Physical Geography, v. 4, no. 3, p. 391-413.}"
}

@misc{austin1984catastrophes2,
    author = "Austin, S. A",
    title = "Catastrophes in Earth History",
    year = "1984",
    howpublished = "A Source Book of Geological Evidence, Speculation and Theory: El Cajon, California, Institute for Creation Research, 318 p.; ICR Technical Monograph 13",
    note = "talkorigins\_source = {true}; raw\_reference = {Austin, S. A., 1984, Catastrophes in Earth History: A Source Book of Geological Evidence, Speculation and Theory: El Cajon, California, Institute for Creation Research, 318 p.; ICR Technical Monograph 13.}"
}

@book{berggren1984catastrophes3,
    author = "Berggren, W. A. and Van Couvering, J. A",
    title = "Catastrophes and Earth History",
    year = "1984",
    publisher = "The New Uniformitarianism: Princeton, New Jersey, Princeton University Press, 465 p",
    note = "talkorigins\_source = {true}; raw\_reference = {Berggren, W. A., and Van Couvering, J. A., 1984, Catastrophes and Earth History: The New Uniformitarianism: Princeton, New Jersey, Princeton University Press, 465 p.}"
}

@article{zenger1986lyell18,
    author = "Zenger, D. H",
    title = "Lyell and episodicity",
    year = "1986",
    journal = "Journal of Geological Education, v. 34, p. 10-13",
    note = "talkorigins\_source = {true}; raw\_reference = {Zenger, D. H., 1986, Lyell and episodicity: Journal of Geological Education, v. 34, p. 10-13.}"
}

@article{culliton1988scientists,
    author = "Culliton, Barbara J.",
    title = "Scientists Confront Misconduct",
    year = "1988",
    journal = "Science",
    url = "https://doi.org/10.1126/science.3175613",
    doi = "10.1126/science.3175613",
    number = "4874",
    pages = "1748-1749",
    volume = "241"
}

@incollection{chapman1989catastrophism,
    author = "Chapman, Clark R. and Morrison, David",
    title = "Catastrophism Gone Wild: The Case of Immanuel Velikovsky",
    year = "1989",
    booktitle = "Cosmic Catastrophes",
    url = "https://doi.org/10.1007/978-1-4899-6553-0\_13",
    doi = "10.1007/978-1-4899-6553-0\_13",
    openalex = "W44934322",
    pages = "183-196"
}

@article{crossref1991catastrophism,
    title = "Catastrophism: systems of earth history",
    year = "1991",
    journal = "Choice Reviews Online",
    url = "https://doi.org/10.5860/choice.28-4543",
    doi = "10.5860/choice.28-4543",
    number = "08",
    openalex = "W333513029",
    pages = "28-4543-28-4543",
    volume = "28"
}

@article{crossref2004perilous,
    title = "Perilous planet earth: catastrophes and catastrophism through the ages",
    year = "2004",
    journal = "Choice Reviews Online",
    url = "https://doi.org/10.5860/choice.41-4058",
    doi = "10.5860/choice.41-4058",
    number = "07",
    openalex = "W4240659375",
    pages = "41-4058-41-4058",
    volume = "41"
}

@article{koeberl2004perilous,
    author = "Koeberl, Christian",
    title = "Perilous planet Earth—Catastrophes and catastrophism through the ages: by Trevor Palmer",
    year = "2004",
    journal = "Meteoritics \& Planetary Science",
    url = "https://doi.org/10.1111/j.1945-5100.2004.tb00345.x",
    doi = "10.1111/j.1945-5100.2004.tb00345.x",
    number = "2",
    openalex = "W2015930546",
    pages = "347-348",
    volume = "39"
}

@article{grattan2005book,
    author = "Grattan, John P",
    title = "Book Review: Perilous planet Earth: catastrophes and catastrophism through the ages",
    year = "2005",
    journal = "The Holocene",
    url = "https://doi.org/10.1177/095968360501500519",
    doi = "10.1177/095968360501500519",
    number = "5",
    openalex = "W2045757096",
    pages = "778-778",
    volume = "15"
}

@article{hampton2005scientists,
    author = "Hampton, T.",
    title = "Scientists Confront Cloning Challenges",
    year = "2005",
    journal = "JAMA: The Journal of the American Medical Association",
    url = "https://doi.org/10.1001/jama.294.7.783",
    doi = "10.1001/jama.294.7.783",
    number = "7",
    openalex = "W2021509334",
    pages = "783-784",
    volume = "294"
}

@article{crossref2012the,
    title = "The Velikovsky heresies: Worlds in collision and ancient catastrophes revisited",
    year = "2012",
    journal = "Choice Reviews Online",
    url = "https://doi.org/10.5860/choice.49-6260",
    doi = "10.5860/choice.49-6260",
    number = "11",
    pages = "49-6260-49-6260",
    volume = "49"
}

@article{doi101016jenfcle2025102150,
    author = "Oter-Quintana, Cristina and Alameda-Cuesta, Almudena",
    title = "Catastrophism, myalgic encephalomyelitis-chronic fatigue syndrome and fibromyalgia: How research questions 'construct' realities.",
    year = "2025",
    journal = "Enfermeria clinica",
    url = "https://pubmed.ncbi.nlm.nih.gov/40288641/",
    doi = "10.1016/j.enfcle.2025.102150",
    pmid = "40288641"
}

Schmerzen im Zusammenhang mit Verletzungen sind eine komplexe Erfahrung, die sowohl objektive als auch subjektive Aspekte verbindet und die Rehabilitationsergebnisse von Sportverletzungen stark beeinflusst. Sie können sich direkt auswirken (z. B. durch eine Verringerung des Bewegungsumfangs und der Kraft der für die Physiotherapie erforderlichen Bewegungen) oder indirekt (z. B. durch geringere Therapieadhärenz, reduzierte psychologische Bereitschaft). Kognitive Faktoren wie Grübeln und katastrophisierendes Denken können die Wahrnehmung von Schmerzen beeinflussen und eine Rolle im Schmerzmanagement von Athleten während dieses Prozesses spielen. Diese Studie hat das Ziel, prospektiv die prädiktive Rolle des grüblerischen und katastrophisierenden Denkens in der Schmerzwahrnehmung bei verletzten Athleten zu untersuchen. Insgesamt wurden 22 verletzte männliche Fußballspieler rekrutiert (durchschnittliches Alter = 20,3 Jahre; SD = .991). Die verwendeten Erhebungsinstrumente waren ein ad-hoc-Fragebogen zu personenbezogenen und sportbezogenen Variablen; ein Fragebogen zu aktueller Verletzung und sportbedingter Verletzungsgeschichte; die Pain Catastrophizing Scale (PCS); die Ruminative Response Scale (RRS); und die Visual Analogue Scale (VAS) for Pain. Die Ergebnisse zeigten einen signifikanten Zusammenhang zwischen Katastrophismus, ruminativen Reaktionen und der Schmerzwahrnehmung bei verletzten Athleten. Athleten mit höherem Ausmaß an Katastrophismus und Grübeln berichteten konsistent über eine höhere Schmerzwahrnehmung. Diese Ergebnisse unterstreichen die Bedeutung gezielter und maßgeschneiderter individueller psychologischer Interventionen im Schmerzmanagement zur Verbesserung der Ergebnisse des Rehabilitationsprozesses. Die Berücksichtigung individueller Bewältigungsstrategien könnte die Genesungsergebnisse verbessern und einen wirksameren Rückkehr-zum-Sport-Prozess unterstützen.

@article{doi101038s41598025292470,
    author = "Gómez-Espejo, Verónica and Olmedilla, Aurelio and García-Mas, Alejandro and Ortega-Toro, Enrique and Sánchez-Iglesias, Iván and Rubio, Victor J",
    title = "Rumination catastrophism and pain in injured athletes.",
    year = "2025",
    journal = "Scientific reports",
    abstract = "Pain associated to injuries is a complex experience that combine both objective and-subjective elements and which strongly affects rehabilitation outcomes of sport injuries. It may affect directly (e.g., reducing range and strength of the movements involved in the physical therapy), or indirectly (e.g., decreasing adherence, reducing psychological readiness). Cognitive factors such as rumination and catastrophic thinking may affect the perception of pain and play a role in athletes management of pain during this journey. This study is aimed at longitudinally examine the predictive role of ruminative and catastrophism thinking in the perception of pain among injured athletes. A total of 22 injured male soccer players were recruited (Mean age = 20.3 years old; SD =.991). The assessment instruments used were ad hoc questionnaire of personal and sports-related variables; a questionnaire of current injury and sports injury history; the Pain Catastrophizing Scale (PCS); the Ruminative Response Scale (RRS); and the Visual Analogue Scale (VAS) of Pain. The results showed a significant relationship between catastrophism, ruminative responses, and the perception of pain in injured athletes. Athletes with higher levels of catastrophism and rumination consistently reported a greater perception of pain. These results highlight the importance of targeted and tailored personalized psychological interventions for pain management to improve the rehabilitation process outcomes. Addressing individual coping strategies could improve recovery outcomes and support a more effective return -to-sport process.",
    url = "https://pmc.ncbi.nlm.nih.gov/articles/PMC12764906/",
    doi = "10.1038/s41598-025-29247-0",
    pmcid = "PMC12764906",
    pmid = "41365976"
}

Das Konzept von Ferenczi, die Verwechslung der Sprachen zwischen der Sprache der Zärtlichkeit des Kindes und der Sprache der Leidenschaft des Erwachsenen, erklärt, dass sich das Kind in Anwesenheit eines Aggressors, der die traumatischen Handlungen zurückweist, sowohl körperlich als auch psychisch hilflos und allein fühlt und dadurch verwirrt ist, ob das traumatische Erlebnis überhaupt stattgefunden hat. Vollständig von Erwachsenen abhängig, nimmt das Kind durch Introjektion von Schuld und Hass des Aggressors an, um die Beziehung zu den Erwachsenen aufrechtzuerhalten. Die Verwirrung im „Sprachen“-Kontext ist mit dem komplexen Konstrukt von Ferenczi, der Identifikation mit dem Aggressor, zum Verständnis äußerer Traumata verbunden. Mit dem Konzept der „autistisch-kontiguen Position“ beschreibt Ogden einen Bereich vorsprachlicher, sinnlich-sensibler Erfahrung, der vor allem an der Oberfläche der Haut als Ausgangspunkt des psychischen Lebens liegt. Diese beiden Konzepte können es uns ermöglichen, Einstellungen und Überzeugungen bei der Erkundung individueller und kollektiver Abwehrmechanismen gegen Klimawandel und Umweltkatastrophen zu erfassen. Mit psychoanalytischem Wissen können wir Menschen helfen, die die Schwere des Klimawandels nur ungern vollständig anerkennen, und so schädliches Verhalten in unserer Beziehung zur Nichtmensch-Welt zu verändern. Der Autor kritisiert die wiederholten beängstigenden und bombardierenden Bilder im Fernsehen und im Internet, die eigentlich über Krisen und Katastrophen in der Welt informieren sollen, stattdessen aber psychische Funktionsprozesse lähmen. Er beschreibt, wie Klimaterrorismus das Auftreten verfolgender und primitiver Ängste sowie sogar die Aktivierung psychotischer Abwehrmechanismen begünstigt. Sie fördern die Schwierigkeiten, an tief verankerte Ängste anzuknüpfen, und nehmen ein Verantwortungsgefühl und das Bewusstsein für die eigene Beteiligung an der Entstehung der Schäden.

@article{doi101057s11231025094959,
    author = "Schinaia, Cosimo",
    title = "Catastrophism and catastrophic images: Ferenczi's identification with the aggressor and Ogden's autistic-contiguous position as defence mechanisms.",
    year = "2025",
    journal = "American journal of psychoanalysis",
    abstract = {Ferenczi's concept, the confusion of tongues between the child's language of tenderness and the adult's language of passion, explains that the child feels physically and psychically helpless and alone in the presence of an aggressor who disavows the traumatic acts, creating confusion for the child whether the traumatic experience happened at all. Fully dependent on the adults, the child adopts by introjecting the guilt and hate of the aggressor, in order to maintain the relationship with the adults. The confusion of tongues situation is linked to Ferenczi's complex construct, the identification with the aggressor, in understanding external traumas. With the concept of "autistic-contiguous position," Ogden identifies an area of pre-symbolic experience of a sensory nature, mainly centered on the surface of the skin as the starting point of mental life. These two concepts may permit us to be in touch with attitudes and beliefs in the exploration of individual and group defense mechanisms against climate change and environmental disasters. Using psychoanalytical knowledge, we can try to help people who are reluctant to fully acknowledge the seriousness of climate change, and so to change damaging behaviors in our relationship with the nonhuman world. The author critiques the repeated terrifying and bombarding images on TV and the Internet which would intend to inform about crises and disasters in the world, instead, those images paralyze psychic functioning. He describes how climate terrorism promotes the emergence of persecutory and primitive anxieties, even the activation of psychotic defenses. They foster the difficulties of getting in touch with deep-seated anxieties and remove a sense of responsibility and awareness of one's own participation in the creation of the damage.},
    url = "https://pmc.ncbi.nlm.nih.gov/articles/8853093/",
    doi = "10.1057/s11231-025-09495-9",
    pmcid = "8853093",
    pmid = "40169868"
}

ZIELE: Nach einer totalen Knie-Totalendoprothese (TKA) leiden bis zu 40 % der Patienten unter chronischen Schmerzen. Nur wenige Studien haben sich speziell mit psychosozialen Faktoren als Prädiktoren für chronische Schmerzen nach TKA befasst. Unsere Studie zielt darauf ab, psychosoziale Risikofaktoren für chronische Schmerzen nach TKA zu identifizieren und einen optimalen Schwellenwert für signifikante Werte in der multivariaten Analyse mithilfe einer Receiver-Operating-Characteristic-(ROC-)Kurve zu bestimmen. METHODEN: Dies war eine einzentrenprospektive Studie, die von September 2022 bis September 2023 mit 204 Patienten durchgeführt wurde. Das Durchschnittsalter betrug 70 Jahre (SD 8,59), der durchschnittliche BMI betrug 30,49 kg/m2 (SD 5,29), und 70,60 % der Patienten waren weiblich (144/204). Vor der Operation wurde ein Formular zur Erhebung ausgegeben: Hospital Anxiety and Depression Scale (HADS), State-Trait Anxiety Inventory (STAI)-Y, Amsterdam Preoperative Anxiety and Information Scale (APAIS), Pain Catastrophizing Scale (PCS) und visuelle Analogskala (VAS). Univariate und multivariate logistische Regressionen wurden verwendet, um die mit chronischen Schmerzen verbundenen Risikofaktoren zu bestimmen. Zur Festlegung eines Schwellenwerts der psychologischen Werte, die mit chronischen Schmerzen verbunden sind, wurden ROC-Kurven erstellt. ERGEBNISSE: Insgesamt erfüllten 36 Patienten (17,60 %) die Definition von chronischen Schmerzen, definiert als VAS ≥ 4/10 sechs Monate postoperativ. In der multivariaten Analyse waren die Zugehörigkeit zu den Gruppen Mitarbeiter oder Arbeiter (β = 1,10, 95 % CI 0,20 bis 2,10, p = 0,018), Angst STAI-YB (β = 0,03, 95 % CI 0,01 bis 0,06, p = 0,013) und Katastrophismus PCS (β = 0,04, 95 % CI 0,02 bis 0,06, p < 0,001) mit chronischen Schmerzen nach TKA assoziiert. Mit ROC-Analyse identifizierten wir einen Schwellenwert von 44,5 für Angst STAI-YB (Sensitivität 57,58 %, Spezifität 74,51 %) und von 21,5 für Katastrophismus PCS (Sensitivität 56,25 %, Spezifität 71,90 %) für die Entwicklung chronischer Schmerzen nach TKA. SCHLUSSFOLGERUNG: Diese Studie zeigt, dass das psychosoziale Profil der Patienten mit dem Auftreten chronischer Schmerzen in Verbindung stehen kann und die Bedeutung eines multidimensionalen Ansatzes für Patientenbeurteilung und -management unterstreicht.

@article{doi1013022633146267bjo20240270r1,
    author = "Croppi, Clara and Delaigue, Fanny and Guinebertière, Violaine and Devriese, Flore and Bizot, Pascal and Descamps, Jules and Nizard, Rémy and Bouché, Pierre-Alban",
    title = "Catastrophism and anxiety are risk factors of chronic pain after total knee arthroplasty: a prospective cohort study.",
    year = "2025",
    journal = "Bone \& joint open",
    abstract = "AIMS: After a total knee arthroplasty (TKA), up to 40\% of patients suffer from chronic pain. Few studies have focused specifically on psychosocial factors as predictors of chronic pain after TKA. Our study aims to identify psychosocial risk factors of chronic pain after TKA and to identify an optimal threshold for significant scores in the multivariate analysis, using a receiver operating characteristic (ROC) curve. METHODS: This was a single-centre prospective study conducted from September 2022 to September 2023, involving 204 patients. The mean age was 70 years (SD 8.59), the mean BMI was 30.49 kg/m2 (SD 5.29), and 70.60\% of patients were female (144/204). A form was administered before surgery to collect: Hospital Anxiety and Depression Scale (HADS), anxiety scale State-Trait Anxiety Inventory (STAI)-Y, Amsterdam Preoperative Anxiety and Information Scale (APAIS), Pain Catastrophizing Scale (PCS), and visual analogue scale (VAS). Univariate and multivariate logistic regression was used to determine the risk factors associated with chronic pain. To determine a threshold in the psychological scores associated with chronic pain, ROC curves were performed. RESULTS: A total of 36 patients (17.60\%) met the definition of chronic pain, defined as VAS ≥ 4/10 at six months postoperatively. In the multivariate analysis, to be an employee or worker (β = 1.10, 95\% CI 0.20 to 2.10, p = 0.018), anxiety STAI-YB (β = 0.03, 95\% CI 0.01 to 0.06, p = 0.013), and catastrophism PCS (β = 0.04, 95\% CI 0.02 to 0.06, p < 0.001) were associated with chronic pain after TKA. Using ROC analysis, we identified a threshold value of 44.5 for anxiety STAI-YB (sensitivity 57.58\%, specificity 74.51\%) and of 21.5 for catastrophism PCS (sensitivity 56,25 \%, specificity 71.90\%) of developing chronic pain after TKA. CONCLUSION: This study shows that the psychosocial profile of patients can be linked to the occurrence of chronic pain, and underlines the importance of a multidimensional approach to patient assessment and management.",
    url = "https://pmc.ncbi.nlm.nih.gov/articles/PMC12226953/",
    doi = "10.1302/2633-1462.67.BJO-2024-0270.R1",
    pmcid = "PMC12226953",
    pmid = "40626844"
}

Die Entwicklung von Behandlungsmethoden gegen nicht-kleinzelliges Lungenkarzinom (NSCLC) ist wichtig, um das Problem steigender Mortalität zu verhindern. Die in der klinischen Praxis eingesetzten Behandlungsmethoden sind jedoch unzureichend, um dieses Problem zu beseitigen. Aus diesem Grund wurde untersucht, ob die Kombination von Docetaxel (DTX) und FH535 als Antikrebs-Medikament-Kandidat in A549-Zellen eingesetzt werden kann und ob diese Kombination nach in-vivo-Studien ein Kandidat für die klinische Behandlung sein kann. FH535 ist ein Inhibitor des WNT-Signalwegs und ist für NSCLC bekanntlich überaktiv. In dieser Studie wurden die Wirkungen von DTX und dem NSCLC-Behandlungsinhibitor FH535 auf die Zelllinien A549 und BEAS-2B auf zellulärer Ebene bewertet. Während die antikrebsartige Aktivität in A549-Zellen zunahm, wurden die Dosen mit minimalen toxischen Effekten in BEAS-2B-Zellen mittels Real Time Cell Analysis bestimmt. Mitotische Aktivität, BrdU-Proliferationsassay und Caspase-3,7-Aktivitätsassay wurden für eine detaillierte Analyse der Kombinationsdosis auf zellulärer Ebene durchgeführt. Die Ergebnisse zeigen, dass die kombinierte Dosis in A549-Zellen eine antimittotische Wirkung mit Auslösung von mitotischer Katastrophe verursachte, während in BEAS-2B-Zellen weder der eine noch der andere Wirkstoff toxischer war als allein, was zu reduzierter mitotischer Aktivität und reduzierter BrdU-Aktivität führte und die Zelle in eine mitotische Katastrophe führte, während die Caspase-3,7-Aktivität unverändert blieb. Diese Studie zeigte erstmals die Effekte der Kombination von DTX und FH535 auf die Zelllinien A549 und BEAS-2B.

@article{doi1014715cmb20257129,
    author = "Avşar, Eda Nur and Çetin, İdil",
    title = "Combined use of WNT signal pathway inhibitor FH535 and docetaxel causes mitotic catastrophism and antiproliferative effect in non-small cell lung cancer.",
    year = "2025",
    journal = "Cellular and molecular biology (Noisy-le-Grand, France)",
    abstract = "The development of treatment methods used in the treatment of non-small cell lung cancer (NSCLC) is important to prevent problem of increasing mortality. However, the treatment methods used in clinical settings at the clinic are insufficient to eliminate this problem. For this purpose, it was aimed to determine whether the combination of docetaxel (DTX) and FH535 can be used as an anticancer agent candidate in A549 cells and whether it is a candidate drug combination that can be used in clinical treatment after in vivo studies. FH535 is a WNT signaling pathway inhibitor and is known to be overactive in NSCLC. In this study, the effects of DTX and WNT signaling pathway inhibitor FH535 used in NSCLC treatment on A549 and BEAS-2B cell lines were evaluated at the cellular level. While increasing the anticancer activity in A549 cells, the doses showing minimum toxic effect in BEAS-2B cells were determined by Real Time Cell Analysis method. Mitotic activity, BrdU cell proliferation assay and caspase 3,7 activity assay were performed for detailed analysis of the combination dose at cellular level. The results show that the combined dose had an antimitotic effect on A549 cells, causing mitotic catastrophism, while in BEAS-2B cells neither agent was more toxic than either agent alone, reducing mitotic activity and BrdU activity, leading the cell to mitotic catastrophism, while caspase 3,7 activity was unchanged. This study demonstrated for the first time the effects of the combination of DTX and FH535 on A549 and BEAS-2B cell lines.",
    url = "https://pubmed.ncbi.nlm.nih.gov/39976912/",
    doi = "10.14715/cmb/2025.71.2.9",
    pmid = "39976912"
}